CURRICULUM VITAE

Informatii personale

dr.-felix-brehar-600×338

NUME / PRENUME: Brehar Felix Mircea

NATIONALITATE: romana

E-MAIL: felixbrehar@yahoo.com

DATA NASTERII: 01.03.1976

Experienta operatorie

EXPERIENTA OPERATORIE

Medic primar neurochirurg – Spitalul Clinic de Urgenta „Bagdasar-Arseni” (01.2002-prezent);

Cercetator stiintific – Spitalul Clinic de Urgenta „Bagdasar-Arseni” (01.2002-prezent);

Sef de Lucrari Universitatea de Medicina si Farmacie “Carol Davila”, Bucuresti

Medic neurochirurg : Rezident(2002-2008);

Specialist (2008-2012);

Medic primar (2013-prezent).

ACTIVITATI CLINICE NEUROCHIRURGICALE

1. Experienta in efectuarea procedurilor de neurochirurgie stereotactica – procedura minim invaziva (peste 500 de proceduri efectuate pana in prezent) cu indicatie in:
– biopsia tumorilor cerebrale in scop diagnostic, evitand astfel riscurile unei interventii de mare anvergura neurochirurgicala
– evacuarea chisturilor tumorale si abceselor cerebrale in scop terapeutic

2. Patologia tumorala neurochirurgicala: peste 200 de cazuri de tumori cerebrale primare benigne si maligne, metastaze cerebrale operate pana in prezent.

3. Discopatia vertebrala cervicala: hernie de disc cervicala, stenoza canalului cervicala.

4. Discopatia vertebrala lombara: hernie de disc lombara, stenoza canalului lombar

5. Hidrocefalia copilului si adultului

6. Patologia traumatica neurochirurgicala: fracturi craniene, hematom extradural, subdural, intraparenchimatos.

7. Patologia vasculara cerebrala: anevrisme intracraniene, cavernoame cerebrale.

8. Patologia infectioasa cerebrala: empiem, abcese cerebrale.

Educatie

EDUCATIE

10.2006-06.2010 – Doctorat (Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti)

Doctor in medicina

Titlul tezei: „Rolul terapiilor celulare si moleculare in cadrul tratamentului multimodal al glioblastomului

Disciplina principala: “Patologia tumorala cerebrala: glioblastomul”

01.2002-12.2008 – Rezidentiat (Spitalul Clinic de Urgenta „Bagdasar-Arseni”, Bucuresti)

Medic specialist neurochirurg;

10.1994-06.2000 – Facultatea de medicina (Universitatea de Medicina si Farmacie „Iuliu Hatieganu”, Cluj Napoca)

Medic doctor;

Medicina generala.

STAGII DE PREGATIRE SI DE SUPRASPECIALIZARE:

a. Spitalul Clinic de Urgenta „Bagdasar-Arseni”, Sectia I Neurochirurgie, 2005-2008, Neurochirurgie pediatrica (traumatologia cranio-cerebrala a copilului, patologia tumorala pediatrica, hidrocefalie, malformatii cranio;

b. Spitalul Universitar Marburg, Germania, (2006)Neurochirurgia tumorala cerebrala, cerebrala vasculara si neurochirurgia bazei craniului;

c. Curs de pregatire a trialurilor clinice “Good Clinical Practice-Training” (2006);

d. Universitatea Virginia, Charlottesville, SUA, Departamentul de Neurochirurgie si de patologie a tumorilor cerebrale (2006);

e. Clinica Universitara Grosshadern, Munich, Germania(2008) Training in neurochirurgia stereotactica: biopsia leziunilor cerebrale in scop diagnostic, evacuarea chisturilor si abceselor cerebrale in scop terapeutic, implantarea intratumorala cerebrala a radioizotopilor (brahiterapie interstitiala), terapia fotodinamica laser in tumorile.

Stagii de pregatire neurochirurgie

Curs de microchirurgie a bazei craniului, Zurich, Elvetia, August 2010

Curs citogenetica moleculara, Institutul National de Cercetare in Domeniul Patologiei si Stiintelor Biomedicale “Victor Babes”, Bucuresti, Aprilie – Iulie 2011

Curs de endoscopie si neurochirurgie minim invaziva, Cluj Napoca, Romania, Decembrie 2012

Curs “Basic Neurosurgical Skills, First edition”, organizat sub egida Societatii Studentilor Chirurgi din Romania, Bucuresti, 10-14 Iulie, 2012

Curs de microchirurgie vasculara si a bazei craniului, colaborare intre Spitalul Clinic de Urgenta “Bagdsar-Arseni”, UMF “Carol Davila” si Walter E. Dandy Neurosurgical Society (I), Bucuresti, 7-10 Iulie 2012

Curs de microchirurgie vasculara si al bazei craniului, Walter E. Dandy Neurosurgical Society, Saint Louis, SUA, Martie 2013

Curs de microchirurgie vasculara si a bazei craniului, colaborare intre Spitalul Clinic de Urgenta “Bagdsar-Arseni”, UMF “Carol Davila” si Walter E. Dandy Neurosurgical Society (II), Bucuresti, Iulie 2013

Curs de microchirurgie vasculara (tehnici de anastomoza vasculara “by pass” pe modele experimentale “in silico”), colaborare intre Spitalul Clinic de Urgenta “Bagdsar-Arseni” si Clinica Cardarelli Napoli, Italia, (I), Bucuresti, Iulie 2015

Curs de microchirurgie vasculara (tehnici de anastomoza vasculara “by pass” pe modele in vivo) (II), Bucuresti, Iulie 2016

Aptitudini

LIMBA MATERNA: Romana

LIMBA ENGLEZA:

-Ascultare si Citire: C1;

-Participare la conversatie: C1;

-Discurs oral: B1.

APTITUDINI DE OPERARE PC:

-Word, Excel, Power Point, Adobe.

PERMIS DE CONDUCERE: Categoria B.

Articole de specialitate

ARTICOLE SI ABSTRACTE PUBLICATE IN REVISTE ISI 

1. Supratentorial epidural hematoma of traumatic etiology in infants. Ciurea AV, Kapsalaki EZ, Coman TC, Roberts JL, Robinson JS 3rd, Tascu A, Brehar F, Fountas KN. Childs Nerv Syst. 2007 Mar;23(3):335-41. Epub 2006 Oct 24.
2. Lethal recurrent hemorrhages of a brainstem cavernoma. Ciurea AV, Nastase C, Tascu A, Brehar FM. Neurosurg Rev. 2007 Jul;30(3):259-62; discussion 262. Epub 2007 May 4
3. Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts, Otilia Zarnescu, Felix Mircea Brehar, Mihaela Chivu, Alexandru Vladimir Ciurea, J Mol Histol. 2008 Dec;39(6):561-9
4. Recent advancements in biomaterials for spinal cord injurycomplex therapeutics, G. Onose, A. V. Ciurea, R. E. Rizea, C. Chendreanu, A. Anghelescu, M. Haras, F. Brehar, Digest Journal of Nanomaterials and Biostructures, Vol. 2, No. 4 , p. 307-314,
5. Isolation and partial characterization of a new human glioblastoma cell line, F. M. Brehar, Coralia Bleotu, Laura Mihaela Stefan, Wanda Buzgariu, Mihaela Chivu, Elena Utoiu, Lilia Matei, A.V. Ciurea, A. Tascu., Chirurgia (Bucur). 2009 Jul-Aug; 104(4):453-61.
6. Morphological and immunohistochemical characterization of U87 glioblastoma xenografts in nude mice, Otilia Zarnescu, Felix Mircea Brehar, Mihaela Chivu, In: Abstracts of XXXIII Congress of the Italian Society of Histochemistry, Roma, 8-10 June, 2009, European Journal of Histochemistry, volumul 53, Supplement 1, pag. 55
7. Immunohistochemical comparison between human glioblastoma multiforme and their xenografts derived from cancer stem cells in nude mice , Otilia Zarnescu, Felix Mircea Brehar, Coralia Bleotu, Mihai Lisievici, Alexandru Vladimir Ciurea, In: Abstracts of 22nd Biennial Joint Meeting of the International Society for Neurochemistry (ISN) and the Asian Pacific Society for Neurochemistry (APSN), Busan, South Korea, 23-28 august 2009, Journal of Neurochemistry, volumul 110, Supplement 2, pag. 208.

8. Characterization of anaplastic astrocytoma xenografts derived from cancer stem cells in nude mice, O. Zarnescu, F.M. Brehar, C. Bleotu, R.M. Gorgan, 21 Meeting of the European Association for Cancer Research, 26-29 June, Oslo, EJC supplements 8, no. 5 (2010) 83–154
9. Infiltrating growing pattern xenografts induced by glioblastoma and anaplastic astrocytoma derived tumor stem cells. Brehar FM, Ciurea AV, Zarnescu O, Bleotu C, Gorgan RM, Dragu D, Matei L.Chirurgia (Bucur). 2010 Sep-Oct;105(5):685-94
10. Co-localization of PCNA, VCAM-1 and caspase-3 with nestin in xenografts derived from human anaplastic astrocytoma and glioblastoma multiforme tumor spheres. Zarnescu O, Brehar FM, Bleotu C, Gorgan RM. Micron. 2011 Dec;42(8):793-800. Epub 2011 May 6
11. Olfactory groove meningiomas : A retrospective study on 59 surgical cases.Ciurea AV, Iencean SM, Rizea RE, Brehar FM, Neurosurg Rev. 2011 Sep 30. [Epub ahead of print]
12. Immunohistochemical analysis of GFAP-δ and nestin in cerebral astrocytomas. Brehar FM, Arsene D, Brinduse LA, Gorgan MR, BRAIN TUMOR PATHOL. 2015 Apr;32(2):90-8.
13. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A; CENTER-TBI Participants and Investigators, NEUROSURGERY. 2015 Jan;76(1):67-80
14. Preferential Association of Lissencephaly-1 Gene Expression with CD133+ Glioblastoma Cells. Brehar FM, Gafencu AV, Trusca VG, Fuior EV, Arsene D, Amaireh M, Giovani A, Gorgan MR. J Cancer. 2017 May 11;8(7):1284-1291

Articole si abstracte publicate

ARTICOLE SI ABSTRACTE PUBLICATE IN REVISTE INDEXATE IN ALTE BAZE DE DATE

Olfactory ensheathing cells in the treatment of the tethered cord syndrome: case report, St M Iencean, N Ianovici, F M Brehar, Romanian Neurosurgery, vol. XV, nr.2, 2008;

The development of xenograft glioblastoma implants in nude mice brain. Brehar FM, Ciurea AV, Chivu M, Zarnescu O, Radulescu R, Dragu D., J Med Life. 2008 Jul-Sep;1(3):275-86;

A life threatening problem in infants: supratentorial epidural hematoma. Ciurea AV, Tascu A, Brehar FM, Nuteanu L, Rizea R. J Med Life. 2009 Apr-Jun;2(2):191-5;

Actualities and perspectives in neurosurgery.Ciure AV, Lencean SM, Brehar FM., J Med Life. 2008 Jan-Mar;1(1):23-9. Review;

Giant asymptomatic intracranial hydatid cyst in a 3 years oldchild – case report, A. Tascu, A.V. Ciurea, Iulia Vapor, A. Iliescu, F. Brehar, Romanian Neurosurgery (2010) XVII 3: 359 – 363 359;

Intracranian arahnoid cysts in children (ACs), A.V. Ciurea, A. Tascu, A. Iliescu, C. Mihalache, F. Brehar, C. Palade, A. Spatariu, Romanian Neurosurgery (2011) XVIII 1: 68 – 76 69;

Induction of differentiation inhibits the tumorigenic potentialof glioblastoma cancer stem cells, F.M. Brehar, A.V. Ciurea, R.M. Gorgan, Coralia Bleotu, A. Tascu, R.I. Radulescu, Lilia Matei, Otilia Zarnescu, Romanian Neurosurgery (2011) XVIII.

Induction of differentiation inhibits the tumorigenic potentialof glioblastoma cancer stem cells, F.M. Brehar, A.V. Ciurea, R.M. Gorgan, Coralia Bleotu, A. Tascu, R.I. Radulescu, Lilia Matei, Otilia Zarnescu, Romanian Neurosurgery (2011) XVIII.

Carti si capitole de carte

CARTI SI CAPITOLE DE CARTE

1. Carte: Experimental models in glioblastoma research, Felix Brehar, Mircea Gorgan, Nova Science Publishers (Editura indexata ISI), Inc, New York, USA, 2015, ISBN: 978-1-63482-535-1.
2. Carte: Neurochirugia stereotactica, Dr. Felix Brehar, Prof. Mircea Gorgan, Editura Medicala, 2014, Bucuresti, ISBN: 978-973-39-0767-1
3. Carte: Ghid de patologie tumorala neurochirurgicala, Prof. Mircea Gorgan, Dr. F. Brehar, Editura Medicala, 2014, ISBN: 978-973-39-0777-01. Capitol de carte: “Elemente de genetică şi biologie moleculară în tumorile cerebrale primare”, in Tratatul de Neurochirurgie, Vol. I,Coordonator Prof. Dr. Alexandru Vlad Ciurea, Editura Medicala, Bucuresti, 2010, ISBN: 978-973-39-0691-9

4. Capitol de carte: “Actualităţi şi perspective în neurochirurgie”, in Tratatul de Neurochirurgie, Vol. I,Coordonator Prof. Dr. Alexandru Vlad Ciurea, Editura Medicala, Bucuresti, 2010, ISBN: 978-973-39-0691-9
5. Capitol de carte: “Stereotaxia”, in Tratatul de Neurochirurgie, Vol. II, Coordonator Prof. Dr. Alexandru Vlad Ciurea, Editura Medicala, Bucuresti, 2011, ISBN: 978-973-39-0720-6
6. Capitol de carte: “Patologie moleculara si genetica in tumorile cerebrale primare”, in Actualitati in Tumorile Intracraniene, Coordonatori Prof. Dr. A.V. Ciurea, Dr. St.M. Iencean, Editura Universitara, 2011, ISBN: 978-606-591-049-2

Proiecte de cercetare

CERCETARI

Banca de Tumori Cerebrale, Viasan 225 / 2003-2005 – proiect sustinut de Academia de Stiinte Medicale;

CEEX 176/2006, Studii Experimentale Asupra Celulelor Stem Mezenchimale Umane Transfectate In Scopul Dezvoltarii Unei Strategii Terapeutice Inovative A Glioblastomului. Gliostemcel, 2006-2008,Coordonator Stiintific;

PNCDI II, 41_035/2007, Celulele stem neurale tumorale: O noua tinta terapeutica in cadrul tratamentului multimodal al glioamelor cerebrale maligne. Acronim: Tumorstem, 2007-2010, Coordonator Stiintific;

PNCDI II, 42149/2008, Imagini ale traiectelor nervoase (Diffusion Tensor Imaging) integrate unui model anatomic 3D – instrument de diagnostic si tratament, acronim DDTI, 2008-2011, Membru;

PNCDI II, 12-122/2008, Sistem integrat de asistare pentru pacientii cu afectiuni neuromotorii severe Acronim: ASISTSYS, 2008-2011, membru;

Partener asociat in proiect european: P7-Infrastructures-2007-1 Programm Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) grant no. 212111/02.2008 (2008-2011);

ICCTI: International Consortium for Cell Therapy and Immunotherapy, finantat prin programul FP7, CZ.1.07/2.3.00/20.0012 si Ministerul Educatiei din Cehia, 2011-2014, Membru.

Assessment of the role of cancer stem cells in malignant gliomas invasion by immunohistochemical analysis of brain-tumor interface. Director of the project. Young researchers‟ competition. University of Medicine and Pharmacy „Carol Davila‟ Bucharest. Grant no: 28487/30.10.2012

A new anti-invasive experimental strategy for infiltrative malignant gliomas (2013-2016). UEFISCDI, Grant no. 42/30.04.2013

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